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Results for "

caspase-1 activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (16) Adenosine Receptor (1) AIM2 (1) Antibiotic (1) Apoptosis (4) Bacterial (1) Cathepsin (1) COX (2) Influenza Virus (1) Interleukin Related (5) Isotope-Labeled Compounds (1) Lactate Dehydrogenase (1) NF-κB (1) NOD-like Receptor (NLR) (4) Pyroptosis (2) Reactive Oxygen Species (1) RIP kinase (1) SARS-CoV (1) Sodium Channel (1) TNF Receptor (2) Tyrosinase (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (12) Infection (2) Inflammation/Immunology (15) Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Caspase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2617A

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC TFA can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation .

HY-P2091

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

HY-P10084

Ac-VAD-pNA

Caspase Others

Ac-VAD-pNA is a caspase-1 substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .

Ac-VAD-pNA	Caspase	Others
Ac-VAD-pNA is a *caspase-1* substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .

HY-P2617

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation .

HY-136728

Ac-YVAD-AOM

Caspase Cancer

Ac-YVAD-AOM is the inhibitor of caspase-1 that shows antitumor activity .
HY-P5938

Ac-AAVALLPAVLLALLAP-YVAD-CHO

Caspase Cancer

Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable caspase-1 inhibitor that has antitumor activity .

Ac-YVAD-AOM	Caspase	Cancer
Ac-YVAD-AOM is the inhibitor of *caspase-1 that shows antitumor activity* .

Ac-AAVALLPAVLLALLAP-YVAD-CHO	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable *caspase-1 inhibitor that has antitumor activity* .

HY-152670

JC2-11	NOD-like Receptor (NLR) AIM2	Inflammation/Immunology
JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1 .

HY-121988

INF4E	NOD-like Receptor (NLR)	Inflammation/Immunology
INF4E is a potent NLRP3 inflammasome inhibitor. INF4E inhibits caspase-1 and NLRP3 ATPase activities. INF4E shows protection against the IR-induced myocardial injury and dysfunction .

HY-W041489

Chelidonic acid 1 Publications Verification	NF-κB Caspase	Inflammation/Immunology Cancer
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-141622

SDZ 224-015	Interleukin Related Caspase SARS-CoV	Infection Inflammation/Immunology
SDZ 224-015 is an orally active inhibitor of the interleukin-1 beta (IL-1β) converting enzyme and *caspase-1. SDZ 224-015 possesses anti-COVID-19 activity*, targeting M ^pro (IC₅₀ of 30 nM) .

HY-N0619

Mulberroside A 2 Publications Verification	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-B1138

Fenbufen CL-82204	COX Caspase	Inflammation/Immunology
Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .

HY-10081

GS-6201 1 Publications Verification CVT-6883	Adenosine Receptor	Inflammation/Immunology
GS-6201 (CVT-6883) is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (K_i=22 nM) . GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse . GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice .

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-148258

GDC-2394	NOD-like Receptor (NLR) Interleukin Related Caspase	Inflammation/Immunology
GDC-2394 is an orally active and selective NLRP3 inhibitor, and also inhibits IL-1β with IC₅₀s of 0.4 μM (human IL-1β) and 0.1 μM (mouse IL-1β). GDC-2394 inhibits NLRP3-induced caspase-1 activity without inhibiting NLRC4-dependent inflammasome activation .

HY-B1138S

Fenbufen-d9	Isotope-Labeled Compounds COX Caspase	Inflammation/Immunology
Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

HY-155759

HMGB1-IN-2	Others	Inflammation/Immunology Cancer
HMGB1-IN-2 (compound 15) is an inhibitor of highly conserved nuclear protein (HMGB1), showing NO inhibitory effect with IC₅₀ value of 20.2 μM in RAW264.7 cells. HMGB1-IN-2 (30 μM) decreases the level of IL-1 β, TNF-α, caspase-1 p20, inhibits the phosphorylation of NF-κB p65, exhibits anti-apoptotic activity. HMGB1-IN-2 (15 mg/kg; ip) relives kidney injury in septic acute kidney injury mouse. HMGB1-IN-2 inhibits Huh7 cells and A549 cells with IC₅₀s of 77.0 μM, and 82.0 μM, respectively .

HY-P1093

Ac-LEHD-AFC

1 Publications Verification

Caspase Others

Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .
HY-P1009

Z-YVAD-FMK

10+ Cited Publications

Caspase Cancer

Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

Ac-LEHD-AFC 1 Publications Verification	Caspase	Others
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

Z-YVAD-FMK 10+ Cited Publications	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

HY-N0816

Polyphyllin VI 1 Publications Verification	Apoptosis Pyroptosis	Cancer
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces *caspase-1*-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer .

HY-115630

cRIPGBM chloride	RIP kinase Caspase Apoptosis	Cancer
cRIPGBM chloride, an orally active, proapoptotic derivative. cRIPGBM can be generated from glioblastoma multiforme (GBM) cancer stem cells (CSCs). cRIPGBM(chloride) targets to receptor-interacting protein kinase 2 (RIPK2) to induce *caspase 1*-dependent apoptosis. cRIPGBM(chloride) suppresses the formation of RIPK2/TAK1 (prosurvival complex), and increases the formation of **RIPK2/caspase 1** (proapoptotic complex). cRIPGBM(chloride) exerts potent anti-tumor activity in vivo in animal models .

HY-N0530

Dryocrassin ABBA Dryocrassin	Apoptosis Influenza Virus	Cancer
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by *Caspase* .

HY-P0111

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible *caspase-1/5* inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis .

HY-127019

Nigericin	Sodium Channel NOD-like Receptor (NLR) Bacterial Apoptosis Antibiotic Pyroptosis Wnt β-catenin	Infection Cancer
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K ⁺/H ⁺ ionophore, promoting K ⁺/H ⁺ exchange across mitochondrial membranes. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through *caspase 1*/GSDMD in TNBC .

HY-157992

LM-021	Interleukin Related Caspase Lactate Dehydrogenase Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
LM-021 is a coumarin-chalcone derivative with anti-aggregatory, antioxidant, neuroprotective and anti-inflammatory properties which suppresses nitric oxide (NO), IL-1β, IL-6, TNF-α production, CD68 antigen (CD68) and histocompatibility-2 (MHCII) expression. LM-021 also attenuates the increase of *caspase 1* activity, lactate dehydrogenase release and ROS level. LM-021 can be used for neurological research .

Ac-LEHD-AFC 1 Publications Verification	Chromogenic Substrates
Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase .

Ac-WEHD-AFC TFA	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC TFA is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC TFA can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation .

Ac-YVAD-pNA	Caspase	Inflammation/Immunology
Ac-YVAD-pNA is a specific *Caspase-1* substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes .

Ac-VAD-pNA	Caspase	Others
Ac-VAD-pNA is a *caspase-1* substrate. Ac-VAD-pNA can be used to detect caspase-1 activity .

Ac-WEHD-AFC	Caspase	Inflammation/Immunology Cancer
Ac-WEHD-AFC is a *fluorogenic caspase-1* substrate*. Ac-WEHD-AFC can measure caspase-1* fluorogenic activity and can be used for the research of tumor and inflammation .

Z-YVAD-AFC	Peptides	Others
Z-YVAD-AFC is a fluorescent substrate for Caspase-1, which can be used to detect and measure the activity of Caspase-1 .

Ac-YVAD-AOM	Caspase	Cancer
Ac-YVAD-AOM is the inhibitor of *caspase-1 that shows antitumor activity* .

Ac-AAVALLPAVLLALLAP-YVAD-CHO	Caspase	Cancer
Ac-AAVALLPAVLLALLAP-YVAD-CHO is a cell-permeable *caspase-1 inhibitor that has antitumor activity* .

Z-YVAD-FMK 10+ Cited Publications	Caspase	Cancer
Z-YVAD-FMK is a cell-permeable caspase-1 and -4 inhibitor with anti-inflammatory and anti-tumor activities .

Z-WEHD-FMK 2 Publications Verification Z-WE(OMe)HD(OMe)-FMK	Caspase Cathepsin	Cancer
Z-WEHD-FMK is a potent, cell-permeable and irreversible *caspase-1/5* inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC₅₀=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W041489

Chelidonic acid 1 Publications Verification	Classification of Application Fields Chelidonium majus Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Papaveraceae Cancer	NF-κB Caspase
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and *caspase-1* . Chelidonic acid is a glutamate decarboxylase inhibitor, with a K_i of 1.2 μM .

HY-N0619

Mulberroside A 2 Publications Verification	Structural Classification Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Morus alba L. Plants Moraceae Inflammation/Immunology Disease Research Fields	TNF Receptor Interleukin Related Tyrosinase
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N0816

Polyphyllin VI 1 Publications Verification	Structural Classification other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids Cancer	Apoptosis Pyroptosis
Polyphyllin VI, an active saponin, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis. Polyphyllin VI induces *caspase-1*-mediated pyroptosis via the induction of ROS/NF-κB/NLRP3/GSDMD signal axis in non-small cell lung cancer .

HY-N0530

Dryocrassin ABBA Dryocrassin	Infection Structural Classification Classification of Application Fields Dryopteridaceae Source classification Phenols Polyphenols Dryopteris crassirhizoma Nakai Plants Disease Research Fields	Apoptosis Influenza Virus
Dryocrassin ABBA (Dryocrassin) is an orally active phloroglucinol derivative that can be extracted from Phyllopteris officinalis. Dryocrassin ABBA has antitumor and antiviral activity. Dryocrassin ABBA induced apoptosis of human hepatocellular carcinoma cells through mitochondrial pathway mediated by *Caspase* .

HY-N0619A

cis-Mulberroside A Mulberroside D	Stilbenes Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	TNF Receptor Interleukin Related Tyrosinase
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) . Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

Cat. No.	Product Name	Chemical Structure

HY-B1138S

Fenbufen-d9
Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

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caspase-1 activity

Inhibitors & Agonists

Fluorescent Dye

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products